Neuro-inflammation and the Immune System in Dementia
Neuro-inflammation plays a critical role in the development and progression of dementia, including Alzheimer’s disease. Inflammation in the brain is often triggered by the accumulation of amyloid plaques and tau tangles, which activate the immune system’s microglia and astrocytes. While these cells initially protect the brain, chronic activation leads to neuroinflammation, causing neuronal damage and impairing cognitive function.
The immune response in dementia also involves the disruption of the blood-brain barrier and increased release of pro-inflammatory cytokines. Targeting neuroinflammation is a promising area of research, with potential therapies aimed at modulating the immune system to slow disease progression and improve brain health.
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