Therapeutic targets & mechanisms for treatment
Dementia and Alzheimer's disease (AD) as of now exhibits one of the greatest medicinal services issues in the created nations. There is no successful treatment equipped for backing off infection movement. As of late the fundamental concentrate of research on novel pharmacotherapies depended on the amyloidogenic speculation of AD, which places that the beta amyloid (Aβ) peptide is primarily in charge of subjective hindrance and neuronal demise. The objective of such medicines is (a) to diminish Aβ creation through the restraint of β and γ secretase chemicals and (b) to advance disintegration of existing cerebral Aβ plaques. Be that as it may, this approach has turned out to be just unobtrusively viable. Late investigations propose an option methodology fixated on the restraint of the downstream Aβ flagging, especially at the neural connection. Aβ oligomers may cause deviant N-methyl-D-aspartate receptor (NMDAR) initiation postsynaptically by shaping buildings with the phone surface prion protein (PrPC). PrPC is enhanced at the neuronal postsynaptic thickness, where it collaborates with Fyn tyrosine kinase. Fyn enactment happens when Aβ is bound to PrPC-Fyn complex. Fyn causes tyrosine phosphorylation of the NR2B subunit of metabotropic glutamate receptor 5 (mGluR5). Fyn kinase blockers masitinib and saracatinib have ended up being effective in treating AD side effects in trial mouse models of the illness.
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- Sleep Deprivation: Cognitive, Emotional, and Physical Impacts - SLEEP DISORDER 2026 (Netherlands)
- Sleep Disorder - Neuroscience-2026 (UK)
- Sleep Disorders and Cardiometabolic Health - SLEEP DISORDER 2026 (Netherlands)
- Sleep Disorders and Chronobiology - Neuropharmacology_2025 (UK)
- Sleep Disorders and Circadian Rhythm - NEURO CONGRESS 2025 (Canada)
- Sleep Disorders and Neuromodulation Techniques - SLEEP DISORDER 2026 (Netherlands)
- Sleep Disorders and Psychiatric Comorbidities - Mental Health Congress 2026 (France)
- Sleep Disorders and Their Neurological Implications - Neurology Congress 2025 (Spain)
- Sleep Disorders in Children and Adolescents - SLEEP DISORDER 2026 (Netherlands)
- Sleep Disorders in the Elderly - SLEEP DISORDER 2026 (Netherlands)
- Sleep Surgery and Oral Appliance Therapy - SLEEP DISORDER 2026 (Netherlands)
- Spinal Biomechanics and Kinesiology - Spine 2025 (Italy)
- Spinal Cord Injury: Advances in Treatment and Regeneration - Neurology Congress 2025 (Spain)
- Spinal Cord Stimulation and Neuromuscular Recovery - Neurology Conference 2026 (France)
- Spinal Deformities: Diagnosis and Treatment Innovations - Spine 2025 (Italy)
- Spinal Tumors: Diagnosis, Treatment, and Outcomes - Spine 2025 (Italy)
- Spine and Spinal disorders - Neuroscience Congress 2026 (France)
- Spine Disorders in the Aging Population: Challenges and Solutions - Spine 2025 (Italy)
- Sports-Related Spinal Injuries: Diagnosis, Prevention, and Treatment - Spine 2025 (Italy)
- Sports-Related Spine Injuries and Rehabilitation - Spine 2025 (Italy)
- Stem Cells & Brain Repair - Neuroscience 2025 (France)
- Stem Cells Role in Neuro-Biological Treatment - NEUROLOGY-2025 (Spain)
- Stem Cells Role in Neuro-Biological Treatment and Neurodermatology - Neurorehabilitation 2025 (Canada)
- Stigma and Advocacy in Mental Health - EURO MENTAL DISORDER 2026 (France)
- Stroke - Stroke Summit 2025 (UAE)
- Stroke & Neurological Disorders - Neuroscience 2025 (France)
- Stroke and Neurological Disorders - Neuroscience Congress 2026 (France)
- Stroke and recovery - Neuroscience Congress-2025 (France)
- Suicide Prevention and Crisis Intervention - EURO MENTAL DISORDER 2026 (France)
- Suicide Prevention and Intervention Strategies - Mental Health Congress 2026 (France)
- Surgical Frontiers in Peripheral Nerve Injuries - Neurology Conference 2026 (France)
- Synthetic Virology and Genetic Engineering - Virology -2025 (France)
- Technology and Ethical Dilemmas in Psychiatry - Mental Health Congress 2026 (France)
- Telemedicine in Sleep Disorders Diagnosis and Care - SLEEP DISORDER 2026 (Netherlands)
- The Future of Spinal Robotics and Smart Wearable Technologies - Spine 2025 (Italy)
- The Impact of Space Travel and Microgravity on the Spine - Spine 2025 (Italy)
- The Intersection of Mental Health and Chronic Spine Disorders - Spine 2025 (Italy)
- The Role of Nutrition and Lifestyle in Spinal Health - Spine 2025 (Italy)
- Transcranial Magnetic Stimulation and Neuromuscular Plasticity - Neurology Conference 2026 (France)
- Trauma and Stressor-Related Disorders - EURO MENTAL DISORDER 2026 (France)
- Trauma-Informed Care and Global Crises - Mental Health Congress 2026 (France)
- Traumatic brain injury - Neuroscience Congress-2025 (France)
- Traumatic Brain Injury (TBI) - NEURO CONGRESS 2025 (Canada)
- Vaccines and Preventive Strategies - Virology -2025 (France)
- Viral Bioinformatics and Genomics - Virology -2025 (France)
- Viral Diagnostics and Biomarkers - Virology -2025 (France)
- Viral Epidemiology and Data Modeling - Virology -2025 (France)
- Viral Evolution and Adaptation - Virology -2025 (France)
- Viral Hepatitis and Liver Infections - Virology -2025 (France)
- Viral Immunology and Host Response - Virology -2025 (France)
- Viral Pathogenesis and Disease Mechanisms - Virology -2025 (France)
- Virtual Reality and Mixed Reality in Neurorehabilitation - Neurology Conference 2026 (France)
- Virus-Host Cell Interactions - Virology -2025 (France)
- Virus-Induced Autoimmunity and Chronic Conditions - Virology -2025 (France)
- Women’s Health and Medical Cannabis - CANNABIS MARIJUANA 2025 (Netherlands)
- Women’s Mental Health - EURO MENTAL DISORDER 2026 (France)
- Workplace Mental Health and Burnout - Mental Health Congress 2026 (France)
- Young Researcher Forum & Emerging Investigators Track - CANNABIS MARIJUANA 2025 (Netherlands)
- Zoonotic and Vector-Borne Viruses - Virology -2025 (France)