Therapeutic targets & mechanisms for treatment

Dementia and Alzheimer's disease (AD) as of now exhibits one of the greatest medicinal services issues in the created nations. There is no successful treatment equipped for backing off infection movement. As of late the fundamental concentrate of research on novel pharmacotherapies depended on the amyloidogenic speculation of AD, which places that the beta amyloid (Aβ) peptide is primarily in charge of subjective hindrance and neuronal demise. The objective of such medicines is (a) to diminish Aβ creation through the restraint of β and γ secretase chemicals and (b) to advance disintegration of existing cerebral Aβ plaques. Be that as it may, this approach has turned out to be just unobtrusively viable. Late investigations propose an option methodology fixated on the restraint of the downstream Aβ flagging, especially at the neural connection. Aβ oligomers may cause deviant N-methyl-D-aspartate receptor (NMDAR) initiation postsynaptically by shaping buildings with the phone surface prion protein (PrPC). PrPC is enhanced at the neuronal postsynaptic thickness, where it collaborates with Fyn tyrosine kinase. Fyn enactment happens when Aβ is bound to PrPC-Fyn complex. Fyn causes tyrosine phosphorylation of the NR2B subunit of metabotropic glutamate receptor 5 (mGluR5). Fyn kinase blockers masitinib and saracatinib have ended up being effective in treating AD side effects in trial mouse models of the illness.

    Related Conference of Therapeutic targets & mechanisms for treatment

    April 23-24, 2025

    6th Global Summit on Brain Disorders and Therapeutics

    Madrid, Spain
    April 23-24, 2025

    6th International Summit on Mental Disorders and Illness

    Paris, France
    April 24-25, 2025

    6th World Congress on Sleep Disorders and Therapeutics

    Amsterdam, Netherlands
    May 12-13, 2025

    12th International Conference on Stroke and Neurological Disorders

    Toronto, Canada
    May 14-15, 2025

    37th International conference on Mental Health and Psychiatry

    Paris, France
    June 12-13, 2025

    31st International conference on Neurosurgery and Brain Disorders

    Paris, France
    June 16-17, 2025

    19th International Conference on Dementia and Alzheimer Disease

    Frankfurt, Germany
    June 20-21, 2025

    16th International Conference on Stroke, Neurology and Cerebrovascular Diseases

    Paris, France
    June 23-24, 2025

    11th International Conference on Epilepsy & Treatment

    Aix-en-Provence, France
    June 24-25, 2025

    20th Annual Conference on Dementia and Alzheimers Disease

    Chicago, USA
    July 07-08, 2025

    20th World Congress on Vascular Dementia and Neurodegenerative Diseases

    Zurich, Switzerland
    July 07-08, 2025

    30th International Conference on Neurology: Neurochemistry, Neuropharmacology and Neurosciences

    Vancouver, Canada
    July 07-08, 2025

    36th Conference on Clinical Neuroscience and Neurogenetics

    Vancouver, Canada
    July 07-08, 2025

    19th International Conference on Alzheimers Disease & Dementia

    Zurich, Switzerland
    July 07-08, 2025

    35th International Conference on Neurology and Cognitive Neuroscience

    Zurich, Switzerland
    July 14-15, 2025

    10th International Conference on Central Nervous System Disorders & Therapeutics

    Berlin, Germany
    July 17-18, 2025

    31st Annual Summit on Neuroscience & Neurological Disorders

    Amsterdam, Netherlands
    July 23-24, 2025

    15th Global Alzheimers Summit

    Paris, France
    July 24-25, 2025

    18th International Congress on Neurology Surgery

    Dubai, UAE
    July 24-25, 2025

    8th World Congress on Epilepsy and Brain Disorders

    Paris, France
    July 28-29, 2025

    35th World Congress on Neurology and Neuroscience

    Paris, France
    August 25-26, 2025

    20th Annual Congress on Neuroscience

    Aix-en-Provence, France
    September 04-05, 2025

    10th Annual Neurologists and Neurosurgeons Meet

    Vancouver, Canada
    September 15-16, 2025

    39th European Neurology Congress

    Aix-en-Provence, France
    September 25-26, 2025

    12th Annual congress on Stroke and Neurological Disorders

    Zurich, Switzerland
    October 06-07, 2025

    14th International Conference on Brain Disorders and Therapeutics

    Las Vegas, USA
    October 20-21, 2025

    7th World Brain Congress

    Osaka, Japan
    October 23-24, 2025

    8th Global Congress on Spine and Spinal Disorders

    London, UK
    October 29-30, 2025

    5th Annual Dementia Congress

    Amsterdam, Netherlands
    November 03-04, 2025

    11th International Conference on Spine and Spinal Disorders

    Rome, Italy
    November 06-07, 2025

    10th Annual Congress on Pediatric Neurology and Pediatric Surgery

    Dubai, UAE
    November 13-14, 2025

    32nd Cognitive Neuroscience Congress

    Bali, Indonesia
    November 13-14, 2025

    38th International Conference on Neuroscience and Neurochemistry

    Paris, France
    December 04-05, 2025

    17th Global Neurologists Meeting on Neurology and Neurosurgery

    Amsterdam, Netherlands
    February 16-17, 2026

    18th International Conference on Neurology and Neuromuscular Disorders

    Paris, France
    August 25-26, 2025

    30th Global Experts Meeting on Neuroscience and Neuropharmacology

    London, UK

    Therapeutic targets & mechanisms for treatment Conference Speakers

      Recommended Sessions

      Related Journals

      Are you interested in